A symposia session from IAS 2017 on Differentiated Service Delivery and Care: Key Considerations for Successful Scale-up. A panel of Ministries of Health representatives, researchers, civil society, policy makers and implementers described the current state of affairs related to the uptake and implementation of the differentiated service delivery and care policies and reported back on a meeting held in November 2016 by WHO, IAS and partners to adapt the Decision Framework to specific populations – children, adolescents, pregnant and breastfeeding women and key populations (people who inject drugs, sex workers, men who have sex with men, transgender people and people in prison and closed settings). The Key Considerations were described and the evidence needed to expand and learn from these models for all populations.